Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain
Copyright policy )Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain
AbstractThe psychoendocrine evaluation of lamb development has demonstrated that maternal deprivation and milk replacement alters health, behavior, and endocrine profiles. While lambs are able to discriminate familiar and non‐familiar conspecifics (mother or lamb), only lambs reared with their mother develop such clear social discrimination or preference. Lambs reared without mother display no preference for a specific lamb from its own group. Differences in exploratory and emotional behaviors between mother‐reared and mother‐deprived lambs have also been reported. As these behavioural abilities are supported by the brain, we hypothesize that rearing with maternal deprivation and milk replacement leads to altered brain development and maturation. To test this hypothesis, we examined brain morphometric and microstructural variables extracted from in vivo T1‐weighted and diffusion‐weighted magnetic resonance images acquired longitudinally (1 week, 1.5 months, and 4.5 months of age) in mother‐reared and mother‐deprived lambs. From the morphometric variables the caudate nuclei volume was found to be smaller for mother‐deprived than for mother‐reared lambs. T1‐weighted signal intensity and radial diffusivity were higher for mother‐deprived than for mother‐reared lambs in both the white and gray matters. The fractional anisotropy of the white matter was lower for mother‐deprived than for mother‐reared lambs. Based on these morphometric and microstructural characteristics we conclude that maternal deprivation delays and affects lamb brain growth and maturation.
S. Love: post-processing: statistical analysis, MRI acquisition. I. Filipiak: Diffusion MRI sequences. H. Adriaensen: MRI acquisition. F. Elleboudt, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, caregivers. F. Lévy: protocol discussion, 150, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, R1 Medicine (General) / orvostudomány általában, interpretation, results discussion, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, secondary writer. E. Haslin, Maternal Deprivation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, anaesthesia, Magnetic Resonance Imaging, White Matter, Milk, DTI, article reviewing, artificial rearing, MRI, [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], sheep, segmentation. D. Zelena: PHC Balaton (research exchange with Csilla Fazekas) F. Andersson, L. Leroy, white and gray matter, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Chr. Moussu: animal preparation, Animals, L. Barantin: MRI protocole, mothering, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Sheep, [SCCO.NEUR]Cognitive science/Neuroscience, segmentation, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SCCO] Cognitive science, M. Bellardie, C. Fazekas: internship, R850-854 Experimental medicine / kisérleti orvostudomány, bibliography. M. Morisse: technician, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, T1-weighted
S. Love: post-processing: statistical analysis, MRI acquisition. I. Filipiak: Diffusion MRI sequences. H. Adriaensen: MRI acquisition. F. Elleboudt, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, caregivers. F. Lévy: protocol discussion, 150, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, R1 Medicine (General) / orvostudomány általában, interpretation, results discussion, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, secondary writer. E. Haslin, Maternal Deprivation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, anaesthesia, Magnetic Resonance Imaging, White Matter, Milk, DTI, article reviewing, artificial rearing, MRI, [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], sheep, segmentation. D. Zelena: PHC Balaton (research exchange with Csilla Fazekas) F. Andersson, L. Leroy, white and gray matter, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Chr. Moussu: animal preparation, Animals, L. Barantin: MRI protocole, mothering, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Sheep, [SCCO.NEUR]Cognitive science/Neuroscience, segmentation, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SCCO] Cognitive science, M. Bellardie, C. Fazekas: internship, R850-854 Experimental medicine / kisérleti orvostudomány, bibliography. M. Morisse: technician, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, T1-weighted
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