Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications
Copyright policy )Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications
During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex. Ctip2/Satb2 postnatal co-localization defines two distinct neuronal subclasses projecting either to the contralateral cortex or to the brainstem suggesting that Ctip2/Satb2 co-expression may refine their properties rather than determine their identity. Gain- and loss-of-function approaches reveal that the transcriptional adaptor Lmo4 drives this maturation program through modulation of epigenetic mechanisms in a time- and area-specific manner, thereby indicating that a previously unknown genetic program postnatally promotes the acquisition of final subtype-specific features.
- University of Geneva Switzerland
- National Research Institute for Agriculture, Food and Environment France
- Cornell University United States
- Institute of Biology Valrose France
- Université Côte d'Azur France
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, 590, [SDV.GEN] Life Sciences [q-bio]/Genetics, Epigenesis, Genetic, Mice, Somatosensory Cortex/embryology, Ctip2/Satb2 coexpression, Biology (General), epigenetic mechanism, LIM Domain Proteins/metabolism, Matrix Attachment Region Binding Proteins/analysis, Neurons, Tumor Suppressor Proteins/analysis, Q, R, Gene Expression Regulation, Developmental, LIM Domain Proteins, cerebral cortex, Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 616.8, QH301-705.5, Science, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, postnatal differentiation, Repressor Proteins/analysis, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Transcription Factors/analysis, Molecular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Adaptor Proteins, Signal Transducing, [SDV.GEN]Life Sciences [q-bio]/Genetics, Tumor Suppressor Proteins, Matrix Attachment Region Binding Proteins, Somatosensory Cortex, layer V projection neurons, Repressor Proteins, Adaptor Proteins, Signal Transducing/metabolism, Developmental Biology and Stem Cells, Lmo4, Neurons/physiology, Transcription Factors, ddc: ddc:616.8
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, 590, [SDV.GEN] Life Sciences [q-bio]/Genetics, Epigenesis, Genetic, Mice, Somatosensory Cortex/embryology, Ctip2/Satb2 coexpression, Biology (General), epigenetic mechanism, LIM Domain Proteins/metabolism, Matrix Attachment Region Binding Proteins/analysis, Neurons, Tumor Suppressor Proteins/analysis, Q, R, Gene Expression Regulation, Developmental, LIM Domain Proteins, cerebral cortex, Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 616.8, QH301-705.5, Science, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, postnatal differentiation, Repressor Proteins/analysis, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Transcription Factors/analysis, Molecular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Adaptor Proteins, Signal Transducing, [SDV.GEN]Life Sciences [q-bio]/Genetics, Tumor Suppressor Proteins, Matrix Attachment Region Binding Proteins, Somatosensory Cortex, layer V projection neurons, Repressor Proteins, Adaptor Proteins, Signal Transducing/metabolism, Developmental Biology and Stem Cells, Lmo4, Neurons/physiology, Transcription Factors, ddc: ddc:616.8
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