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University of Geneva
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483 Projects, page 1 of 97
  • Funder: European Commission Project Code: 715289
    Overall Budget: 1,498,960 EURFunder Contribution: 1,498,960 EUR

    The centriole is the largest evolutionary conserved macromolecular structure responsible for building centrosomes and cilia or flagella in many eukaryotes. Centrioles are critical for the proper execution of important biological processes ranging from cell division to cell signaling. Moreover, centriolar defects have been associated to several human pathologies including ciliopathies and cancer. This state of facts emphasizes the importance of understanding centriole biogenesis. The study of centriole formation is a deep-rooted question, however our current knowledge on its molecular organization at high resolution remains fragmented and limited. In particular, exquisite details of the overall molecular architecture of the human centriole and in particular of its central core region are lacking to understand the basis of centriole organization and function. Resolving this important question represents a challenge that needs to be undertaken and will undoubtedly lead to groundbreaking advances. Another important question to tackle next is to develop innovative methods to enable the nanometric molecular mapping of centriolar proteins within distinct architectural elements of the centriole. This missing information will be key to unravel the molecular mechanisms behind centriolar organization. This research proposal aims at building a cartography of the human centriole by elucidating its molecular composition and architecture. To this end, we will combine the use of innovative and multidisciplinary techniques encompassing spatial proteomics, cryo-electron tomography, state-of-the-art microscopy and in vitro assays and to achieve a comprehensive molecular and structural view of the human centriole. All together, we expect that these advances will help understand basic principles underlying centriole and cilia formation as well as might have further relevance for human health.

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  • Funder: European Commission Project Code: 101022703
    Overall Budget: 304,724 EURFunder Contribution: 304,724 EUR

    How do artisans approach their role as educators? As part of long-standing research on world craft practices and their social, cultural, and economic dimensions, anthropologists have been paying attention to processes of learning: how aspiring practitioners acquire skills and know-how through participation in social settings. The influence of these studies extends well beyond the boundaries of anthropology, to inform research in the social sciences of learning. Within this research, scant attention has been given to the perspectives of artisans, who are not just skilled practitioners but also often skilled educators. To redress this, this project proposes to develop the concept of artisan pedagogies, to denote the skills and understandings that artisans develop through the practice of teaching and mentoring novices. It will do so by taking social interactions in the context of practice-based learning as its focal point of investigation, and recognising that diverse forms of craft provide unique perspectives onto learning. The research develops an innovative and inter-disciplinary methodology, combining sociolinguistics (conversation and interaction analysis) approaches with ethnographic methods (participant observation, apprenticeship as method). It deploys a participatory approach to elicit artisans’ implicit understandings about how novices learn, and implicit work and social ethics. The methodology will be applied to two empirical case studies addressing dry-stone masonry in Switzerland and Taiwan, allowing for a comparative dimension based on exploration of pedagogies in relation to procedures, culture and the environment. The study will lead to re-evaluating key theories and concepts in the anthropology and social sciences of learning, in light of expert practitioners' own understandings and practices.

  • Funder: European Commission Project Code: 294650
  • Funder: European Commission Project Code: 250117
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  • Funder: European Commission Project Code: 255185

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