Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius
Copyright policy )Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius
With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G (2-4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1-13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.
- French National Centre for Scientific Research France
- Institut de Chimie des Substances Naturelles France
- University of Paris-Saclay France
- University of Geneva Switzerland
- University of Lausanne Switzerland
Euphorbiaceae/chemistry, Nuclear Magnetic Resonance, Antineoplastic Agents, Drug Screening Assays, Stilbenes/chemistry/isolation & purification/pharmacology, 615, Stilbenes, Humans, Nuclear Magnetic Resonance, Biomolecular, Phytogenic/chemistry/isolation & purification/pharmacology, Flavonoids, Prenylation, Flavonoids/chemistry, Molecular Structure, Euphorbiaceae, Plant Leaves/chemistry, Antitumor, Antineoplastic Agents, Phytogenic, Plant Leaves, Fruit/chemistry, Vietnam, Fruit, Drug Screening Assays, Antitumor, Biomolecular, ddc: ddc:615
Euphorbiaceae/chemistry, Nuclear Magnetic Resonance, Antineoplastic Agents, Drug Screening Assays, Stilbenes/chemistry/isolation & purification/pharmacology, 615, Stilbenes, Humans, Nuclear Magnetic Resonance, Biomolecular, Phytogenic/chemistry/isolation & purification/pharmacology, Flavonoids, Prenylation, Flavonoids/chemistry, Molecular Structure, Euphorbiaceae, Plant Leaves/chemistry, Antitumor, Antineoplastic Agents, Phytogenic, Plant Leaves, Fruit/chemistry, Vietnam, Fruit, Drug Screening Assays, Antitumor, Biomolecular, ddc: ddc:615
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