Carnivore depredation of livestock is a global problem which negatively impacts both agropastoral livelihoods and carnivore population viability. Given the gravity of this issue, research has increasingly focused on applied techniques capable of quantifying the factors that increase the risk of livestock depredation. One such technique is risk modeling. This multivariate approach is designed to produce predictions of the spatial configuration of depredation so as to prioritize interventionist activities. Thus, the efficacy of subsequent interventions is, in part, dependent upon the accuracy of the predictions deriving from the risk models. The predictability of spatial patterns in carnivore depredation of livestock is influenced by the degree of spatial autocorrelation evident in the data distributions. We conducted a multi-year assessment to quantify the degree of spatial autocorrelation within livestock depredation data. We centered our study in the Maasai steppe of Tanzania, which experiences some of the highest rates of human-carnivore conflict in the world. We applied three geostatistical measures to assess spatial clustering in data describing livestock depredation by lions (Panthera leo), leopards (Panthera pardus), spotted hyenas (Crocuta crocuta), black-backed jackals (Canis mesomelas), and cheetahs (Acinonyx jubatus) at the household (i.e., livestock enclosure) scale. Using an ordinal spatial scan statistic, a Bernoulli spatial scan statistic, and the Getis-Ord local spatial statistic, we found that the spatial patterns in carnivore depredation of livestock tended not to significantly differ from random. As the predictive ability of spatial risk models may be limited where spatial patterns of carnivore depredation of livestock do not statistically differ from random, explicitly assessing such patterns is an important component of conflict mitigation efforts. We discuss the inferences of this analysis for the optimization of interventionist activities intending to develop sustainable solutions for human-carnivore conflict.