Self-determination theory (SDT) was used to explain the relation of parental autonomy support for making their own decisions and career well-being (i.e., more academic major satisfaction and less subjective career distress). Perceived academic competence and perceived volitional autonomy were posited to mediate the relation of mother’s and father’s autonomy support and career well-being in 113 university students. Perceived academic competence mediated the relation of father’s support and both indicators of career well-being. Perceived volitional autonomy mediated the relation of mother’s support and both indicators of career well-being. A bootstrap procedure yielded significant mediation effects of mother’s and father’s autonomy support on career well-being. Results are discussed in terms of SDT and career well-being.