Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2023 Peru, Turkey, Sweden, Belgium, Portugal, France, United Kingdom, Qatar, Italy, Denmark, Greece, Italy, United Kingdom, Chile, France, Poland, Poland, France, Italy, Finland, Italy, United Kingdom, France, Sweden, Italy, France, Spain, Netherlands, Finland, Italy, Austria, Australia, Belgium, Germany, Denmark, Italy, United States, United Kingdom English Publisher:Springer Science and Business Media LLCJournal:Nature Medicine, volume 29, pages 2,885-2,901 (issn: 1078-8956, eissn: 1546-170X,

Copyright policy )Publicly fundedFunded by:UKRI | Worldwide phenotypes and ...

Authors: null, null; Zhou, Bin; Sheffer, Kate E.; Bennett, James E.; Gregg, Edward W.; Danaei, Goodarz; Singleton, Rosie K.; +193 Authors

null, null; Zhou, Bin; Sheffer, Kate E.; Bennett, James E.; Gregg, Edward W.; Danaei, Goodarz; Singleton, Rosie K.; Shaw, Jonathan E.; Mishra, Anu; Lhoste, Victor P. F.; Carrillo-Larco, Rodrigo M.; Kengne, Andre P.; Phelps, Nowell H.; Heap, Rachel A.; Rayner, Archie W.; Stevens, Gretchen A.; Paciorek, Chris J.; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Vander Hoorn, Stephen; Lu, Yuan; Pavkov, Meda E.; Imperatore, Giuseppina; Aguilar-Salinas, Carlos A.; Ahmad, Noor Ani; Anjana, Ranjit Mohan; Davletov, Kairat; Farzadfar, Farshad; González-Villalpando, Clicerio; Khang, Young-Ho; Kim, Hyeon Chang; Laatikainen, Tiina; Laxmaiah, Avula; Mbanya, Jean Claude N.; Narayan, K. M. Venkat; Ramachandran, Ambady; Wade, Alisha N.; Zdrojewski, Tomasz; Abbasi-Kangevari, Mohsen; Rahim, Hanan F. Abdul; Abu-Rmeileh, Niveen M.; Adambekov, Shalkar; Adams, Robert J.; Aekplakorn, Wichai; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Agyemang, Charles; Ahmadi, Ali; Ahmadi, Naser; Ahmadi, Nastaran; Ahmed, Soheir H.; Ajlouni, Kamel; Al-Hinai, Halima; Al-Lahou, Badreya; Al-Lawati, Jawad A.; Asfoor, Deena Al; Al Qaoud, Nawal M.; Alarouj, Monira; AlBuhairan, Fadia; AlDhukair, Shahla; Aldwairji, Maryam A.; Ali, Mohamed M.; Alinezhad, Farbod; Alkandari, Abdullah; Alomirah, Husam F.; Aly, Eman; Amarapurkar, Deepak N.; Andersen, Lars Bo; Anderssen, Sigmund A.; Andrade, Dolores S.; Ansari-Moghaddam, Alireza; Aounallah-Skhiri, Hajer; Aris, Tahir; Arlappa, Nimmathota; Aryal, Krishna K.; Assah, Felix K.; Assembekov, Batyrbek; Auvinen, Juha; Avdičová, Mária; Azad, Kishwar; Azimi-Nezhad, Mohsen; Azizi, Fereidoun; Bacopoulou, Flora; Balakrishna, Nagalla; Bamoshmoosh, Mohamed; Banach, Maciej; Bandosz, Piotr; Banegas, José R.; Barbagallo, Carlo M.; Barceló, Alberto; Baretić, Maja; Barrera, Lena; Basit, Abdul; Batieha, Anwar M.; Batista, Aline P.; Baur, Louise A.; Belavendra, Antonisamy; Ben Romdhane, Habiba; Benet, Mikhail; Berkinbayev, Salim; Bernabe-Ortiz, Antonio; Berrios Carrasola, Ximena; Bettiol, Heloísa; Beybey, Augustin F.; Bhargava, Santosh K.; Bika Lele, Elysée Claude; Bikbov, Mukharram M.; Bista, Bihungum; Bjerregaard, Peter; Bjertness, Espen; Bjertness, Marius B.; Björkelund, Cecilia; Bloch, Katia V.; Blokstra, Anneke; Bo, Simona; Bobak, Martin; Boggia, Jose G.; Bonaccio, Marialaura; Bonilla-Vargas, Alice; Borghs, Herman; Bovet, Pascal; Brajkovich, Imperia; Brenner, Hermann; Brewster, Lizzy M.; Brian, Garry R.; Briceño, Yajaira; Brito, Miguel; Bugge, Anna; Buntinx, Frank; Cabrera de León, Antonio; Caixeta, Roberta B.; Can, Günay; Cândido, Ana Paula C.; Capanzana, Mario V.; Čapková, Naděžda; Capuano, Eduardo; Capuano, Rocco; Capuano, Vincenzo; Cardoso, Viviane C.; Carlsson, Axel C.; Casanueva, Felipe F.; Censi, Laura; Cervantes‐Loaiza, Marvin; Chamnan, Parinya; Chamukuttan, Snehalatha; Chan, Queenie; Charchar, Fadi J.; Chaturvedi, Nish; Chen, Huashuai; Cheraghian, Bahman; Chirlaque, María-Dolores; Chudek, Jerzy; Cifkova, Renata; Cirillo, Massimo; Claessens, Frank; Cohen, Emmanuel; Concin, Hans; Cooper, Cyrus; Costanzo, Simona; Cowell, Chris; Crujeiras, Ana B.; Cruz, Juan J.; Cureau, Felipe V.; Cuschieri, Sarah; D'Arrigo, Graziella; d'Orsi, Eleonora; Dallongeville, Jean; Damasceno, Albertino; Dastgiri, Saeed; De Curtis, Amalia; de Gaetano, Giovanni; De Henauw, Stefaan; Deepa, Mohan; DeGennaro, Vincent; Demarest, Stefaan; Dennison, Elaine; Deschamps, Valérie; Dhimal, Meghnath; Dika, Zivka; Djalalinia, Shirin; Donfrancesco, Chiara; Dong, Guanghui; Dorobantu, Maria; Dörr, Marcus; Dragano, Nico; Drygas, Wojciech; Du, Yong; Duante, Charmaine A.; Duboz, Priscilla; Dushpanova, Anar; Dziankowska-Zaborszczyk, Elzbieta; Ebrahimi, Narges; Eddie, Ricky; Eftekhar, Ebrahim; Efthymiou, Vasiliki; Egbagbe, Eruke E.; Eghtesad, Sareh; El-Khateeb, Mohammad; El Ati, Jalila;

doi: 10.1038/s41591-023-02610-2 , 10.60692/tsn21-22243 , 10.60692/egd5y-6wj71 , 10.5281/zenodo.8169145 , 10.5281/zenodo.8169146

pmid: 37946056

pmc: PMC10667106

handle: 10230/70860 , 11351/11449 , 11370/7c14f6f0-0e22-4ec8-ba10-f7c77e98a751 , 20.500.12831/19610 , 20.500.14243/536227 , 10576/60598 , 10400.21/16643 , 10447/619472 , 20.500.12008/54614 , 11383/2168155 , 11379/620690 , 11386/4850091 , 20.500.12866/14709 , 2158/1350079 , 1854/LU-01HEZBC2Z8JJWBMRC1Q0BZ9R8S , 2318/1945280 , 1959.4/unsworks_85619 , 10044/1/107086

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

- Summary
- Subjects
- Metrics

Abstract

AbstractFasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

Countries

Peru, Turkey, Sweden, Belgium, Portugal, France, United Kingdom, Qatar, Italy, Denmark, Greece, Italy, United Kingdom, Chile, France, Poland, Poland, France, Italy, Finland, Italy, United Kingdom, France, Sweden, Italy, France, Spain, Netherlands, Finland, Italy, Austria, Australia, Belgium, Germany, Denmark, Italy, United States, United Kingdom

Related Organizations

National Research Institute for Agriculture, Food and Environment
France
Xi'an Jiaotong University
China (People's Republic of)
UNIVERSITY OF PATRAS
Greece
University of Southern Denmark
Denmark
Agricultural Research Council
Italy

View all View all

Keywords

Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología, 3125, diagnosis, Epidemiology, Endocrinology, Diabetes and Metabolism, 32 Biomedical and Clinical Sciences, Glycemic biomarkers, Research & Experimental Medicine, Global Health, [SHS]Humanities and Social Sciences, 3121, glukoosi, Glycated hemoglobin, Diabetes mellitus, Endocrinology, Sociology, middle aged, hemoglobiini, middle income country, Purification, 11 Medical and Health Sciences, Genetics and Pathogenesis of Type 1 Diabetes, PLASMA-GLUCOSE, anzsrc-for: 42 Health Sciences, diabetes, adult, Life Sciences, General Medicine, ta3142, Fasting, Management of Diabetes Mellitus and Hypoglycemia, Impaired fasting glucose, Medicine, Research & Experimental, Endokrinologi och diabetes, diabetes mellitus, Type 1 Diabetes, General Biochemistry, Genetics and Molecular Biology; General Medicine, NCD Risk Factor Collaboration (NCD-RisC), Medicine, 4.2 Evaluation of markers and technologies, Biochemistry & Molecular Biology, fasting, DIABETES MELLITUS, Immunology, 610, Endocrinology and Diabetes, 3142, General Biochemistry, Genetics and Molecular Biology, CLASSIFICATION, Article, Separation, Public Health; Epidemiology;, anzsrc-for: 32 Biomedical and Clinical Sciences, HBA1C, SDG 3 - Good Health and Well-being, COMPUESTOS QUÍMICOS Y DROGAS::hidratos de carbono::azúcares::monosacáridos::hexosas::glucosa::glucosa sanguínea, Health Sciences, Diabetes Mellitus, Genetics, Epidemiología, 303009 Ernährungswissenschaften, Humans, Blood Glucose; Diabetes Mellitus; Glycated Hemoglobin, human, Hemoglobin, Demography, Glycated Hemoglobin, Fasting glucose, Science & Technology, high income country, undiagnosed disease, DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus, Biology and Life Sciences, Diagnostic markers, Biomarker, major clinical study, glucose blood level, Glucose, Glucèmia, FOS: Biological sciences, EPIDEMIOLOGÍA, asting glucose, Other subheadings::Other subheadings::Other subheadings::/epidemiology, HEMOGLOBINA GLUCADA, 610 Medizin und Gesundheit, diagnoosi, Diabetes; cardiovascular diseases, BETA-CELL DYSFUNCTION, low income country, [SDE] Environmental Sciences, Blood Glucose, Settore MED/09 - Medicina Interna, HEALTH CARE::Population Characteristics::Health::Global Health, Medizin, 4202 Epidemiology, anzsrc-for: 4202 Epidemiology, Precipitation, GLUCOSA, South Asia, Hemoglobin A1c (HbA1c), Glucose Metabolism, 03 Salud y bienestar, Diagnosis, Medicine and Health Sciences, Prevalence, blood glucose, Diabetes Mellitus/diagnosis, glucose, hemoglobin A1c, Internal medicine, Diabetes diagnosis, RISK, Diabetis - Epidemiologia, Plasma glucose, ddc:610, INSULIN-RESISTANCE, Public health, sairastavuus, Diagnóstico, GLUCEMIA, Diabetes, BLOOD-GLUCOSE, Global, Type 2 diabetes, 03 Good health and well-being, Diagnostic criteria for diabetes, FOS: Sociology, HUMANOS, female, ATENCIÓN DE SALUD::Características de la Población::salud::salud global, Environmental health, DIAGNÓSTICO, SDG 3 – Gesundheit und Wohlergehen, [SHS] Humanities and Social Sciences, Fasting plasma glucose (FPG), Metabolic Syndrome and Cardiovascular Disease, Medicina y salud, fasting blood glucose level, Life Sciences & Biomedicine, LiOH production, prevalence, Population, UNITED-STATES, GLYCATED HEMOGLOBIN, Salud Pública, Glycemic status, CHEMICALS AND DRUGS::Carbohydrates::Sugars::Monosaccharides::Hexoses::Glucose::Blood Glucose, male, Biochemistry, Genetics and Molecular Biology, Life Science, Blood glucose, Sports and Exercise Medicine, Metabolic and endocrine, AYUNO, 42 Health sciences, Salut mundial, Electrochemical, 42 Health Sciences, Impaired glucose tolerance, Insulin resistance, PREVALENCIA, Cell Biology, 32 Biomedical and clinical sciences, Liikuntalääketiede, diagnostiikka, 3111, Hypoglycemia, ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus, anzsrc-for: 11 Medical and Health Sciences, HBA(1C), Continuous Glucose Monitoring, 303009 Nutritional sciences, glycated hemoglobin

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	81
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%