Smart Cities have already attracted attention as one of the possible solutions to improve “livability” and people’s quality of life. Beyond 5G and 6G are candidate technologies to positively impact aspects of immense social value as sustainability, resilience, inclusion, trust, security, etc. TrialsNet vision is to enable the realization of compelling societal values through the implementation of 5G and beyond applications, which will be propaedeutic for the transition towards the next generation of mobile networks. Based on this, TrialsNet will deploy full large-scale trials to implement a heterogenous and comprehensive set of innovative 6G applications based on various technologies such as Cobots, Metaverse, massive twinning, Internet of Senses, and others, covering the three relevant domains of the urban ecosystems in Europe identified as i) Infrastructure, Transportation, Security & Safety, ii) eHealth & Emergency, and iii) Culture, Tourism & Entertainment”. This future ecosystem is on course to be more collaborative and inclusive than previous generations of network, and TrialsNet aims to lead the way by promoting open architectures, large experimentation sites and taking a multi-stakeholder approach with the objective to connect the digital with the physical and natural worlds. TrialsNet will propose technological innovations towards real-life services in the communication area, to enable Europe to achieve a leading position also in the standardization process (e.g., 3GPP, ETSI) thus securing a leading position for Europe in the global ICT market over the coming years. Thanks to its activities, TrialsNet will contribute to Europe’s technological leadership in communication technologies and in future emerging enabling technologies, by strengthening European capacities in key parts of future services