The design of future innovative, sustainable and circular aircraft configurations arises the necessity to extend the branches of the aeronautical research to the entire aircraft life-cycle, from the design to the production, to the disposal after the end of the system activity. In this frame, within the EU-funded H2020 AGILE 4.0 project, the concurrent coupling of the three domains of product design, manufacturing and supply chain has been addressed by levering Model-Based Systems Engineering (MBSE) and Multidisciplinary Design and Optimization (MDO) technologies The MBSE models and the MDO preliminary results related to the three- dimensional approach applied to a specific aircraft component, that is the horizontal tail plane, are addressed in this research activity and presented in the paper.