The geodynamic evolution of the Alps suggests that the Alps did not rise monotonically due to the different post-collisional processes such as slab break-off. However, understanding such subsurface dynamics would require adequate knowledge about its surface uplift history. Stable isotope paleoaltimetry methods are widely used to infer past surface elevation using geologic archives. However, its accurate interpretation relies on attributing the extracted isotopic signal from proxies to surface uplift despite other influences such as climate. To resolve this issue, topographic sensitivity experiments across the Alps are used to investigate the impacts of the diachronous surface uplift on regional climate and δ18Op. The Atmospheric General Circulation Model ECHAM5 with water isotope tracking capabilities (ECHAM5-wiso) is used to simulate the climate with varied topographic scenarios. We present the processed (long-term means) model output of the relevant climate variables (i.e δ18Op, near-surface temperature, precipitation amount, near-surface meridional and zonal winds, mean sea level pressure, and elevation) in response to the changes in topography. The file names are representative of the topographic scenarios used for the simulations. For example, the file “W2E1.nc” is the model output produced by a topographic scenario in which the topography across the west-central Alps was set to 200% of its modern height, and the Eastern Alps were kept at 100%. The “CTL.nc” file contains model output from the control simulation that uses present-day topography. The datasets for instance can be used to select far-field sampling points for the δ-δ paleoaltimetry method that are not significantly affected by the topographic changes.