Neutrino Non Standard Interactions (NSI) can lead to sub-dominant effects in the oscillation patterns of neutrinos propagating through the Eath’s matter. Indeed, these interactions would modify the flavour ratio of the atmospheric neutrino flux detected at the Earth’s surface. KM3NeT is a next-generation neutrino telescope currently under construction in the Mediterranea Sea. KM3NeT/ORCA is a dense array that constitutes the low-energy branch of KM3NeT with the main aim of determining the neutrino mass ordering. The first data sample was gathered with the six-line configuration referred to as ORCA6, which was operating between January 2020 and November 2021. In this contribution, we present the first results on NSI with the ORCA6 detector. The limits obtained with only about 5% of the final detector size reveal the KM3NeT/ORCA potential to provide world-leading NSI measurements in the near future.