This is the English version of the Open Letter addressed to Prime Minister of the Croatian Government, Andrej Plenkovi��, minister of science and education, Radovan Fuchs, and to the Croatian media outlets on 2 Nov 2021. The Open Letter emphasizes six fundamental principles and suggests six measures based on which we believe the quality and international recognition of research&innovation and higher education in the Republic of Croatian could be improved. The Croatian version can be found here: https://zenodo.org/record/5005986 The names of four authors and 26 supporters are listed below. Authors (alphabetically): Pavel Gregori��, PhD, Institute of Philosophy, Croatia Prof Mirko Planini��, Faculty of Science, University of Zagreb, Croatia Prof Vlatko Silobr��i��, Croatian Academy of Sciences and Arts, Croatia Tomislav Stojanov, PhD, University of Nottingham, UK Supporters (alphabetically): Tome Anti��i��, PhD, Ru��er Bo��kovi�� Institute, Croatia Prof Marija Brajdi�� Vukovi��, Institute for Social Research in Zagreb, Croatia Prof Neven Budak, Faculty of Humanities and Social Sciences, University of Zagreb, Croatia Prof Hrvoje Buljan, Faculty of Science, University of Zagreb, Croatia Prof Bla��enka Divjak, Faculty of Organization and Informatics, University of Zagreb, Croatia Mladen Domazet, PhD, Institute for Political Ecology, Croatia Prof Josip Glaurdi��, Universit�� du Luxembourg, Luxembourg Prof Ita Grui�� Sovulj, Faculty of Science, University of Zagreb, Croatia Prof ��eljko Ivezi��, University of Washington, USA Prof Dejan Jovi��, Faculty of Political Science, University of Zagreb, Croatia Prof Hrvoje Klasi��, Faculty of Humanities and Social Sciences, University of Zagreb, Croatia Prof Hrvoje Kraljevi��, Faculty of Science, University of Zagreb, Croatia Dragomira Majhen, PhD, Ru��er Bo��kovi�� Institute, Croatia Prof Sini��a Male��evi��, University College, Dublin, Ireland Prof Guy Pai��, Universidad Nacional Aut��noma de M��xico, Mexico Prof Nenad Pavin, Faculty of Science, University of Zagreb, Croatia Prof Darko Pol��ek, Faculty of Humanities and Social Sciences, University of Zagreb, Croatia Petra Posedel ��imovi��, Assistant Professor, Faculty of Agriculture, University of Zagreb, Croatia Prof Aleksandra Ra��enovi��, ��cole Polytechnique F��d��rale de Lausanne, Switzerland Nenad Raos, PhD, research advisor, retired, Croatia Prof Hrvoje ��iki��, Faculty of Science, University of Zagreb, Croatia Prof Zvonimir ��iki��, University of Zagreb, retired, Croatia Prof Aleksandar ��tulhofer, Faculty of Humanities and Social Sciences, University of Zagreb, Croatia Prof Iva Toli��, Ru��er Bo��kovi�� Institute, Croatia Prof Maja Vehovec, University of Rijeka, retired, Croatia Prof Igor ��uti��, University of Buffalo, USA