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Two-dimensional mass spectrometry (2D MS) is a method for tandem mass spectrometry that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.
analytical_chemistry, ELECTRON-CAPTURE DISSOCIATION, IMPROVE, Organic chemistry, 2D FT-ICR, Article, phase correction, QD241-441, two-dimensional, [CHIM] Chemical Sciences, RESOLUTION ION ISOLATION, tandem mass spectrometry, SPECTRA, absorption mode, CELL, mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing, FRAGMENTATION, OPTIMIZATION, data processing, GENERATION, mass spectrometry
analytical_chemistry, ELECTRON-CAPTURE DISSOCIATION, IMPROVE, Organic chemistry, 2D FT-ICR, Article, phase correction, QD241-441, two-dimensional, [CHIM] Chemical Sciences, RESOLUTION ION ISOLATION, tandem mass spectrometry, SPECTRA, absorption mode, CELL, mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing, FRAGMENTATION, OPTIMIZATION, data processing, GENERATION, mass spectrometry
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