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Phase Correction for Absorption Mode Two-dimensional Mass Spectrometry

Authors: van Agthoven, Maria A; Breuker, Kathrin; Delsuc, Marc-André;

Phase Correction for Absorption Mode Two-dimensional Mass Spectrometry

Abstract

Two-dimensional mass spectrometry (2D MS) is a method for tandem mass spectrometry that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.

Countries
Austria, France
Keywords

analytical_chemistry, ELECTRON-CAPTURE DISSOCIATION, IMPROVE, Organic chemistry, 2D FT-ICR, Article, phase correction, QD241-441, two-dimensional, [CHIM] Chemical Sciences, RESOLUTION ION ISOLATION, tandem mass spectrometry, SPECTRA, absorption mode, CELL, mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing, FRAGMENTATION, OPTIMIZATION, data processing, GENERATION, mass spectrometry

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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