Abstract This article reports on the linguistic and cultural adaptation of Items of the National Quality of Life Survey (NQLS 2018), which are included in a National Survey that explores the availability of reasonable accommodation for Deaf users in a health care setting as well as health care access. We document the cultural and linguistic adaptation step-by-step, guided by a literature review, participatory group discussions, and qualitative testing. This research addresses the dearth of accessible research instruments for D‍/‍deaf persons in low and middle-income countries. This lack of accessible tools leads to double layers of exclusion, and data gaps often lead to erroneous generalizations that do not accurately represent D‍/‍deaf populations. Evidence gaps may result in poor service planning and inadequate policymaking. This study contributes to good practices in language interpreting in research settings, disability research, and global health.