Human rights have been threatened in recent years globally especially in Nigeria where human rights situation has continued to deteriorate. This study investigated human rights promotion in the south east Nigeria and the influence of Christian religious education among primary school teachers. The study adopted descriptive cross sectional research design. The population of the study comprised of all the public primary school teachers of CRS from the five South-East states in Nigeria. The researchers selected only 100 professional trained CRE teachers using accidental sampling techniques. Structured questionnaire was used to collect data while Mean and Standard Deviation was used to analyze the data. The result revealed the overall mean scores of (= 3.2). This indicated that CRE has an influence in the promotion of fundamental human right among the population. The result of the study further indicated that CRE has an influence in the promotion of morals and principles towards the promotion of fundamental human rights, with the overall mean scores of (= 3.21). Again, the mean scores of (= 3.3), revealed the influence of effective teaching of CRE in schools for the promotion of human fundamental right in the south eastern Nigeria. The study concluded that the School managers and teachers should fully recognize the aims and objectives of CRE and should emphasize the Christian virtues in daily activities of the school as a way of indoctrinating them with the basic social teachings of Jesus as embedded in the National Policy of Education.