Being socially excluded or receiving a negative feedback leads individuals to implement emotion regulation strategies to deal with their negative emotions. In four experiments (total N = 534), we examined the moderating impact of Interoceptive Accuracy (i.e., IAcc, as measured with the heartbeat counting task) and Interoceptive Sensibility (IS, assessed via questionnaire) on negative affect, following social exclusion or after receiving a negative feedback. Results from an integrative meta-analysis combining the four studies confirmed that the manipulations were successful at inducing negative affect. However, no significant interaction between condition and interoception on negative mood measures was revealed, and this was true both for objective (i.e., IAcc) and subjective (i.e., IS) measures of interoception. Hence, previous conclusions on the moderating impact of interoception neither replicated nor generalized on this large sample.