Hemiboeaalbiflora X.G.Xiang, Z.Y.Guo & Z.W.Wu, sp. nov., a new species of Gesneriaceae from Guizhou, China, is described and illustrated. This species was previously listed informally as a variety of H.gamosepala, but it differs significantly from H.gamosepala by its 5-parted calyx from the base, longer peduncle, white corolla and longer pistil. Based on recent extensive observations, this new species is similar to H.cavalerieivar.paucinervis and H.subcapitata but differs from them by its longer petiole, larger involucre, white corolla and longer staminal filaments. The conservation status of this species is considered to be “Vulnerable” (VU) according to the IUCN Red List Categories and Criteria.