Cerambycidae is one the most diverse families in the order Coleoptera with more than 37,000 species described in all continents. Cerambicyd beetles have a worldwide distribution from sea level to montane sites. In Mexico, more than 1,600 species have been recorded. Nevertheless, the diversity and distribution of this family in the Mexican deserts is poorly known. A first checklist of Cerambycidae from seven localities of Cuatro Ciénegas Basin is presented. This study is the result of sampling carried out between 2009 to 2013. Some material from other collections is also included. The species list includes four subfamilies, 13 tribes, 32 genera and 37 species, from which 13 are new records for the state of Coahuila and three species represent new records for Mexico. These results highlight the paucity of knowledge of insects in the deserts of Mexico.