The North-East region in India is recognized as a major hotspot of biodiversity with a vast range of flora and fauna. The region extends from the plain areas such as the Barak-Brahmaputra Valley of Assam to the mountainous regions of Nagaland and Arunachal Pradesh. The population in the region is just as diverse as its biodiversity with people residing in plain areas as well as in the hilly and mountainous areas. The vast forest area and availability of forest resources provide food, medicine, and, to some extent, livelihood for the different Indigenous people residing in the region; and hence their dependency and relationship with forest resources are tight knitted. The Karbi tribe is an ethnic community residing in the Karbi Anglong district in Assam state of the NE region. Their knowledge of forest resources, familiarity with the intricacies associated with it, utilization of various plants is found in the natural habitats for everyday purposes along with owning small and micro-farms have made them quite adaptable to the hilly environment. In the past, the Karbis mainly resided in the mountainous and hilly areas; but to access better facilities, most of the people have migrated and settled in the plains. The era of connectivity and urbanization has affected the forest areas that have gradually led to the loss of plants in their wild natural habitat, some of which hold a significant cultural identity and religious beliefs. In the present day, the younger generation has shifted from old ties and traditions, which might have contributed to the loss of knowledge about plants used for various purposes and certain Indigenous practices.