This article aims to increase knowledge and find the best practices on how sustainable energy management (SEM) can be boosted and implemented at a regional level. It presents the main results from the RESGen (RES Generation – From Research Infrastructure to Sustainable Energy and Reduction of CO2 Emissions) project (subsidized by the EU in 2009-2012) and the procedure developed within the project, which aims to support regionally comprehensive implementation of SEM involving all the main stakeholders. Physical prerequisites to support the transition of the energy sector towards SEM exist. The renewable energy sources (RES) potential is vast, the economics, especially regional impacts, are feasible, general perceptions are positive, technologies are evolving and the majority of stakeholders support this agenda. There are however barriers slowing the process. The RESGen procedure provides a structured and strategic approach for the shift towards SEM.