The five-factor model (FFM) is a representation of the patterns of covariation of personality traits in terms of five broad factors. The Revised NEO Personality Inventory, a questionnaire measure of the FFM, has recently been translated into a number of different languages, permitting tests of its cross-cultural replicability. Data from Filipino and French translations are presented, showing clear and detailed replication of the American normative factor structure when targeted rotation is used. Results from these and other cross-cultural and behavior genetic studies suggest that the FFM is a biologically based human universal. Applications of trait psychology in clinical, educational, and organizational settings may prove generalizable across cultures, and cross-cultural psychologists can profitably explore the expression of the same personality traits in different cultural contexts.