NASA employs Design Reference Missions (DRMs) to define potential architectures for future human exploration missions to deep space, the Moon, and Mars. While DRMs to these destinations share some components, each mission has different needs. This paper focuses on the identified human and automation/robotic integration needs for these future missions. The outcomes of our assessment is a human and automation/robotic (HAR) high-level task list for each of the four DRMs that we reviewed (i.e., Deep Space Sortie, Lunar Visit/Habitation, Deep Space Habitation, and Planetary), as well as a list of common critical HAR factors that drive the design of HAR integration.