AbstractFuel cells powered by biogas for decentralised cogeneration of heat and power are an attractive alternative to combustion technologies. However, biogas contains sulfur-based compounds (H2S, COS, DMS, siloxanes), which are harmful to fuel cells. This work was carried out in the framework of the European project Waste2Watts, involving the laboratories of Politecnico di Torino, ENEA, and PSI. The aim is to design and test a flexible and cost-effective cleaning unit to remove impurities for the use of biogas in high-efficiency fuel cell systems. The focus is on small- to medium-sized farms for which deep cleaning of biogas by adsorption materials is a suitable techno-economic solution to avoid intensive gas processing treatments. The ability of commercial adsorption materials (activated carbons, metal oxides, and metal hydroxides) to remove hydrogen sulphide and carbonyl sulphide was tested under different biogas compositions (oxygen and humidity). After evaluating the results, three plant configurations were proposed to optimally utilise the potential of the sorbents. Indeed, the RGM3 sorbent has proven to be an effective solution for removing H2S and COS under humid conditions (50% RH), whilst R7H and R8C sorbents are better suited for removing H2S and COS, respectively, in dry biogas conditions. Graphical abstract