One of the most promising approaches to overcome the end of Moore's law is neuromorphic computing. Indeed, neural networks already have a great impact on machine learning applications and offer very nice properties to cope with the problems of nanoelectronics manufacturing, such as a good tolerance to device variability and circuit defects, and a low activity, leading to low energy consumption. We present here N2S3 (for Neural Network Scalable Spiking Simulator), an open-source simulator that is built to help design spiking neuromorphic circuits based on nanoelectronics. N2S3 is an event-based simulator and its main properties are flexibility, extensibility, and scalability. One of our goals with the release of N2S3 as open-source software is to promote the reproducibility of research on neuromorphic hardware. We designed N2S3 to be used as a library, to be easily extended with new models and to provide a user-friendly special purpose language to describe the simulations.