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University of Lille
Country: France
119 Projects, page 1 of 24
  • Funder: EC Project Code: 276358
  • Funder: EC Project Code: 101030083
    Overall Budget: 184,708 EURFunder Contribution: 184,708 EUR

    The aim of the project is two-fold. One goal is to employ techniques from smooth 4-dimensional topology in the study of deformations of isolated surface singularities. More specifically the project aims at advancing in the study of smoothings of rational surface singularities by means of gauge-theoretic invariants as well as lattice-theoretic combinatorial techniques. A conjecture of Kollar regarding a class of rational surface singularities with a unique smoothing will be considered. The conjecture has natural symplectic and topological counterparts. The plan consists in proving the topological version and investigating the extent to which this version of the problem can lead to advancements in the original conjecture. Another primary goal is to investigate properties of the 3-dimensional rational homology sphere group, such as n-divisibility and torsion, via constructions involving rational cuspidal curves in possibly singular homology planes. In this context a first specific goal is producing examples of 3-manifolds which are either Seifert fibered spaces or obtained via Dehn surgery on an algebraic knots which are 2-divisible in the rational homology sphere group. In a similar setting it will be investigated the extent to which rational homology balls bounded by integral surgeries on torus knots can be realized algebraically.

  • Funder: EC Project Code: 290424
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  • Funder: EC Project Code: 101067300
    Funder Contribution: 195,915 EUR

    How do you nurture democracy in a republic? Today, as republics around the world are straining under the pressures of authoritarianism, this question becomes almost overwhelmingly urgent. In helping to draw the blueprints for United States republicanism, Thomas Jefferson gave his answer in temporal terms: the U.S. would remain democratic as long as each generation was given power to “repair” the Constitution to suit their era, but also the obligation of handing on that document, with the entire republic, in a peaceful and timely manner to the next generation. This pattern of generational succession, which Jefferson believed would prevent any one generation from permanently stamping their likeness on the country, became essential to nineteenth-century Americans’ socio-political outlook: to be a truly democratic republic, they believed, required living in this new temporal order, which has yet to be identified by scholarship and which I am calling “republican time.” The goal of my research project, executed under the co-supervision of Hélène Quanquin and Hélène Cottet (University of Lille, France), is to investigate the relationship between republican time and the workings of democracy in nineteenth-century America. I will accomplish this goal through a program of close reading of American literature, informed by theories of political science, history, race, and gender and sexuality.

  • Funder: EC Project Code: 101066684
    Funder Contribution: 195,915 EUR

    The alarmingly high incidence of obesity, particularly in children, highlights the need to better understand the factors and mechanisms involved in the early development of this pathological condition. Accumulating evidence, including work from the host lab, support the idea that the maternal nutritional environment could influence the offspring’s susceptibility to develop obesity and related comorbidities in later life. In particular, there is growing appreciation that developmental malprogramming of hypothalamic neuroendocrine system by the perinatal environment represents a possible cause for these diseases. However, the mechanisms by which the maternal environment affects hypothalamic development and predisposition to obesity are still largely unknown. We hypothesize that the maternal gut microbiota (mGM) conditions, in the offspring, the development of hypothalamic structures with lifelong metabolic consequences. We will test this novel hypothesis by using two complementary animal models of impaired mGM: germ-free dams and dams with antibiotic-induced alteration of gut microbiota during pregnancy and lactation. We will assess neuroanatomical organization of hypothalamic feeding circuits, structural and functional development of blood-brain barrier as well as metabolic outcomes in the offspring. Finally, we will examine the cause and effect relationship between mGM and hypothalamic development and function by determining whether i) maternal fecal material transplant and ii) dams’ supplementation with specifically identified microbial metabolites prevent offspring’s neuroanatomical and metabolic alterations. Completion of this project will i) shed light on a new vertical role of mGM on hypothalamic neurodevelopment and metabolic programming and ii) identify new potential drivers leading to early-life metabolic disorders. Given the high prevalence of maternal antibiotic use and childhood obesity, this project could have a potential impact on public health.


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