UDL

The aim of the project is two-fold. One goal is to employ techniques from smooth 4-dimensional topology in the study of deformations of isolated surface singularities. More specifically the project aims at advancing in the study of smoothings of rational surface singularities by means of gauge-theoretic invariants as well as lattice-theoretic combinatorial techniques. A conjecture of Kollar regarding a class of rational surface singularities with a unique smoothing will be considered. The conjecture has natural symplectic and topological counterparts. The plan consists in proving the topological version and investigating the extent to which this version of the problem can lead to advancements in the original conjecture. Another primary goal is to investigate properties of the 3-dimensional rational homology sphere group, such as n-divisibility and torsion, via constructions involving rational cuspidal curves in possibly singular homology planes. In this context a first specific goal is producing examples of 3-manifolds which are either Seifert fibered spaces or obtained via Dehn surgery on an algebraic knots which are 2-divisible in the rational homology sphere group. In a similar setting it will be investigated the extent to which rational homology balls bounded by integral surgeries on torus knots can be realized algebraically.

Perspective taking, the ability to take another person's perspective, is instrumental in building successful and harmonious partnerships, from romantic relationships to international cooperation. Yet, failure to achieve perspective taking, or egocentrism, is increasingly observed in clinical and healthy populations. Fortunately, perspective taking is a skill that can be acquired through training, but, to date, existing training has only yielded limited results. This project aims to conduct the first epidemiological study of egocentrism (i.e. to assess its prevalence in Europe, its severity, its psycho-sociological determinants, and its consequences on mental health and well-being) and the first large-scale perspective-taking training intervention for both healthy and clinical populations. By distinguishing the profiles of egocentrism and identifying their key determinants, Work Package (WP) 1 will assess perspective-taking performance (and associated psycho-sociological factors) in Alzheimer, addictive disorder, anorexic, and forensic patients and in matched healthy control participantss. Building on the Supervisor’s team expertise in devising and conducting training interventions, WP2 will devise and conduct intervention programs tailored to the distinct egocentrism profiles in the same populations as WP1. WP3 will export the WP1-WP2 methodology into a free web-based assessment and training tool to conduct the epidemiological study and the large-scale training intervention in the general population, from adolescents to seniors. The assessment and training tool will be made available to all clinicians, researchers and all other actors to foster further uses such as for youth education programs, support programs for caregivers, or mental health promotion programs targeting vulnerable populations.

The alarmingly high incidence of obesity, particularly in children, highlights the need to better understand the factors and mechanisms involved in the early development of this pathological condition. Accumulating evidence, including work from the host lab, support the idea that the maternal nutritional environment could influence the offspring’s susceptibility to develop obesity and related comorbidities in later life. In particular, there is growing appreciation that developmental malprogramming of hypothalamic neuroendocrine system by the perinatal environment represents a possible cause for these diseases. However, the mechanisms by which the maternal environment affects hypothalamic development and predisposition to obesity are still largely unknown. We hypothesize that the maternal gut microbiota (mGM) conditions, in the offspring, the development of hypothalamic structures with lifelong metabolic consequences. We will test this novel hypothesis by using two complementary animal models of impaired mGM: germ-free dams and dams with antibiotic-induced alteration of gut microbiota during pregnancy and lactation. We will assess neuroanatomical organization of hypothalamic feeding circuits, structural and functional development of blood-brain barrier as well as metabolic outcomes in the offspring. Finally, we will examine the cause and effect relationship between mGM and hypothalamic development and function by determining whether i) maternal fecal material transplant and ii) dams’ supplementation with specifically identified microbial metabolites prevent offspring’s neuroanatomical and metabolic alterations. Completion of this project will i) shed light on a new vertical role of mGM on hypothalamic neurodevelopment and metabolic programming and ii) identify new potential drivers leading to early-life metabolic disorders. Given the high prevalence of maternal antibiotic use and childhood obesity, this project could have a potential impact on public health.