A study of HLA antigens and immune response to DNCB in alopecia areata
Copyright policy )A study of HLA antigens and immune response to DNCB in alopecia areata
Summary The frequencies of 10 HLA-A and 14 HLA-B antigens were determined in thirty patients with alopecia areata. Distribution of HLA antigens was studied according to patient's response to a single immunizing dose of 2 mg of 1-chloro-2: 4-dinitrobenzene (DNCB). HLA-A3 was associated with defective immune response. Segregation of patients with alopecia areata into ‘high-responders’ and ‘low-responders’ to DNCB suggests that acquired disturbances of the immune-response may be modulated by genes linked to the major histocompatibility complex.
- University of Lille France
- Université Catholique de Louvain Belgium
Adult, Male, Adolescent, Alopecia Areata, Middle Aged, HLA Antigens, Antibody Formation, Dinitrochlorobenzene, Humans, Female, Child
Adult, Male, Adolescent, Alopecia Areata, Middle Aged, HLA Antigens, Antibody Formation, Dinitrochlorobenzene, Humans, Female, Child
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