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Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential

نباتات القرعيات: التركيز الرئيسي على إمكاناتها الدوائية
Authors: Bahare Salehi; Esra Çapanoğlu; Nabil Adrar; Gizem Çatalkaya; Shabnum Shaheen; Mehwish Jaffer; Lalit Giri; +17 Authors

Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential

Abstract

Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases.

Keywords

Squash, Blood Glucose, antioxidant, Endocrinology, Diabetes and Metabolism, Ethnobotany, Organic chemistry, Review, Antioxidants, Terpenoid, Agricultural and Biological Sciences, Diabetes, Oxidative Stress, and Antioxidants, QD241-441, cucurbits, Anti-Infective Agents, Cucurbit Genetics, Antioxidants / chemistry, Antineoplastic Agents, Phytogenic / chemistry, Life Sciences, Cucurbitacins, Folk medicine, Cucurbitacins / pharmacology, Anticancer, Cucurbita / chemistry, Medicine, Antioxidant, Blood Glucose / drug effects, Cucurbitacins / chemistry, Anti-Infective Agents / pharmacology, Plant Extracts / chemistry, Nutritional and Functional Potential of Ancient Grains, Genetics and Genomics of Cucurbitaceae Family, squash, Phytochemical, anticancer, traditional medicine, Microbiology, Cucurbita, Medicinal plants, Biochemistry, Genetics and Molecular Biology, Health Sciences, Genetics, pumpkin, Humans, Biology, Cucurbits, Antioxidants / pharmacology, Plant Extracts, Antineoplastic Agents, Phytogenic / pharmacology, Anti-Infective Agents / chemistry, Botany, Traditional medicine, Antineoplastic Agents, Phytogenic, FOS: Biological sciences, Ethnopharmacology, antimicrobial, Antimicrobial, Medicine, Traditional, anticancer; antimicrobial; antioxidant; cucurbits; pumpkin; squash; traditional medicine, Pumpkin, Food Science

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    130
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
130
Top 1%
Top 10%
Top 1%
Green
gold