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Universidade Lusófona do Porto
Country: Portugal
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221 Projects, page 1 of 45
  • Funder: EC Project Code: 301177
  • Funder: EC Project Code: 101038087
    Overall Budget: 79,907.5 EURFunder Contribution: 79,907.5 EUR

    In recent years, an increasing number of emerging pollutants were identified in aquatic ecosystems, and one of the major concerns is the presence of sex-steroid hormones and mimics which act on aquatic organisms as endocrine-disrupting compounds (EDCs). The proposed multidisciplinary project will have focus on in vitro testing of complex of EDCs mixtures: the EU watch listed pollutant ethinylestradiol with emergent progestins drugs (levonorgestrel and megestrol acetate), taking into account a standard versus a warming scenario, as a major global change issue. This will be done by developing and exploiting cutting edge in vitro fish toxicity test tools: single-cell and (new in fish studies) multi-cell type 3D spheroids of liver cells (hepatocytes, stellate cells and biliary epithelial cells) of brown trout (Salmo trutta). The project will explore the advantages of 3D cultures, which have been proved to be much more biologically realistic than common 2D cultures, in order to study: (i) their morphology and viability using light and electron microscopy, including immunocytochemistry; (ii) multi end-point biochemical assays in combination with Raman microspectroscopy (novel in 3D culture); (iii) mechanistic insights of disruption and eventual (still unavailable) biomarkers of fish exposure/effect as to progestins. Quantitative gene expression is the method of choice for this task, targeting specific genes related to lipid-metabolism, yolk and eggshell proteins and androgen/estrogen/progestin receptors. An additional innovative contribution of this project is developing new tolls for enforcing the 3Rs (Replacement, Reduction, and Refinement) in fish research. The project will bring to another level the collaboration between the applicant and the host mentor by bidirectional transfer of skills and expertise, while conducting a scientifically innovative project. The strategy will benefit persons while establishing grounds for long-term institutional benefits.

  • Funder: EC Project Code: 251816
  • Funder: EC Project Code: 101108936
    Funder Contribution: 156,779 EUR

    HYLOGLOB aims to reconstruct a long-neglected yet crucial debate among Scholastic philosophers on the ontological constitution of natural bodies. This debate took place in Europe during the 16th c., but its consequences had a global, cross-cultural impact. In their struggle to find a balance among opposite claims about matter, form, and the elements, 16th-c. Scholastic philosophers produced influential ontologies of nature. Their theories, in turn, became the lenses through which European thinkers in China and New Spain engaged with metaphysical and cosmological doctrines that were completely alien to them. The reconstruction of the 16th-c. Scholastic debate on the constitution of natural substances is key to understand the processes of philosophical accommodation and reinterpretation of non-European systems of thoughts that took place in early modern Asia and America. By using a multi-levelled methodology, HYLOGLOB will reconstruct the Scholastic debate on the ontology of nature and its global impact. On the one hand, it will analyse how historical actors addressed apparently unsolvable questions on prime matter, substantial forms, and the elements. On the other, it will assess how these theories were used as influential interpretative tools to grasp sophisticated metaphysical doctrines that utterly diverged from the European tradition. HYLOGLOB’s results will produce, for the first time, a thorough, comprehensive understanding of how 16th-c. thinkers envisioned the constitution of the physical world. It will provide meaningful insights on the tensions between metaphysical and physical considerations of nature, the Jesuits materialistic interpretations of Chinese philosophy, and the foundation of an independent philosophical tradition in New Spain. At the crossroad of different traditions and disciplines, HYLOGLOB will contribute to foster a new, more nuanced understanding of a central aspect of the constitution of European identity in a globalising world.

  • Funder: EC Project Code: 307499
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