Objectives/HypothesisTo investigate whether there is an impact of obesity and overweight on the clinical findings and therapeutic responses of patients with laryngopharyngeal reflux (LPR).Study DesignProspective uncontrolled.MethodsPatients with LPR‐related symptoms and positive LPR diagnosis at the hypopharyngeal‐esophageal multichannel intraluminal impedance pH‐monitoring (HEMII‐pH) were recruited from December 2017 to December 2020. Patients were treated with a combination of diet, proton pump inhibitors, and alginate for 3 to 6 months. The following outcomes were studied according to the weight of patients: HEMII‐pH, gastrointestinal endoscopy features, symptoms, findings, and therapeutic response.ResultsA total of 262 patients completed the study, accounting for 134, 85, and 43 patients with normal weight (body mass index [BMI] <25), overweight (BMI = 25–29.99), and obesity (BMI >30). Obese patients reported significant higher prevalence of gastroesophageal reflux disease (GERD), acid LPR, and a more severe LPR disease regarding the number of pharyngeal reflux events, reflux symptom score (RSS), and reflux sign assessment (RSA). RSS and RSA scores significantly improved from baseline to 3‐month posttreatment irrespective of the patient weight group. Symptoms and signs continued to improve from 3 to 6‐month posttreatment only in patients with a normal weight.ConclusionObesity is associated with a more severe LPR disease and a higher proportion of GERD and acid LPR. Obese LPR patients may require more frequently PPI‐therapy regarding the higher prevalence of GERD.Level of Evidence3 Laryngoscope, 131:E2742–E2748, 2021