Segmentation and specification in the branchial region of the head: the role of the Hox selector genes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998 English Publisher:EHU PressJournal:The International Journal of Developmental Biology, volume 42, pages 393-401 (issn: 0214-6282, eissn: 1696-3547,

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Authors: F M, Rijli; A, Gavalas; P, Chambon;

doi: 10.1387/ijdb.9654024

pmid: 9654024

Segmentation and specification in the branchial region of the head: the role of the Hox selector genes

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Abstract

Hox genes are segmentally expressed in the developing vertebrate hindbrain, neural crest cells and pharyngeal arches suggesting an important role in patterning these structures. Here we discuss the cellular and molecular mechanisms controlling segmentation and specification in the branchial region of the head. In addition, based on the recent phenotypical and molecular analysis of loss-of-function mutants in the mouse, we speculate that Hox genes may act like Drosophila selector genes in this system.

Related Organizations

French National Centre for Scientific Research
France
Institute of Genetics and Molecular and Cellular Biology
France
Collège de France
France

Keywords

Homeodomain Proteins, Genes, Homeobox, Gene Expression Regulation, Developmental, Genes, Insect, Rhombencephalon, Mice, Animals, Drosophila, Body Patterning

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