Recent population recovery of many pinniped species (seals, sea lions, walrus) is a conservation success. However, pinniped population recovery combined with increasing global fisheries operations is leading to increased conflicts between pinnipeds and fisheries. This human-wildlife conflict threatens pinniped conservation outcomes and may impose damaging impacts on fisheries, but the economic consequences and extent of these impacts are poorly understood. Here, we provide a global assessment of pinniped and fisheries operational interactions. We show that a third of reported fishing days have interactions with pinnipeds and 13.8% of catch is lost. Our results also reveal high heterogeneity between studies. Small-scale fisheries are three times more likely to interact with pinnipeds and lose four times as much catch as large-scale fisheries. Finally, we develop a spatial index that can predict where conflict is most likely to occur. Our findings reveal a substantial global issue requiring appropriate management as pinniped populations continue to recover.