Recent research has looked into the potential for energy savings from adopting setpoint temperatures based on adaptive comfort. The recently suggested Adaptive-Comfort-Control-Implementation Script (ACCIS), a computational method that expands the use of air conditioning to adaptive comfort, can be used to accomplish this. The user's setup and an Input Data File (IDF) are used by ACCIS to convert PMV-based EnergyPlus models into adaptive setpoint models. The Adaptive Comfort Control Implemented Model ("accim") Python module has been used to nest ACCIS, which was originally an Energy Management System (EMS) script. This research focuses on the creation of ACCIS and offers a more in-depth understanding of how the computational method functions based on the connections between the objects that compose it. Since all weather file quantity constraints have been overcome and studies can now be generated based on millions of simulations, ACCIS opens up new opportunities for performing energy simulations on a worldwide scale rather than only on a national or continental level. This potential is increased considering that, until recently only international models ASHRAE Standard 55 and European standard EN16798-1 were considered in ACCIS, but now a recent update allows to select local comfort models developed for specific areas. As a result, this potential is firstly demonstrated by means of the study of the 3 arguments that have the most important impact on the setpoint temperatures: the thermal comfort model, the acceptability levels and the behaviour of setpoint temperatures when adaptive comfort models are not applicable; and secondly by means of an actual example of use of accim.