Context Edible stone pine (Pinus pinea L.) nut is a forest product which provides the highest incomes to the owners of stone pine forests. Aim The objective of this work is to evaluate the effect of first thinning on growth and cone production in an artificially regenerated stand in order to determine optimum intensity. Methods A thinning trial was installed in 2004 to compare two thinning regimes (heavy and moderate) and a control treatment. From 2004 to 2012, six inventories of forest attributes were carried out, and the cone crop was harvested annually. We evaluated the effect of thinnings on growth using repeated measures analysis of variance with a mixed model approach. With regards to cone production, we first estimated the probability of finding cones in a tree by applying a generalized mixed model and then estimated cone production by using a mixed model, including climatic variables. Results We found that thinning had a positive influence on tree diameter increment. Thinning increased the probability of finding cones and cone production. However, significant differences between heavy and moderate thinnings were not found. Conclusion We recommend early silvicultural treatments in stone pine stands to favor the development of trees and larger edible pine nut production. © 2013 INRA and Springer-Verlag France.