Evaluation of an Integrated Ultrafiltration/Solid Phase Extraction Process for Purification of Oligomeric Grape Seed Procyanidins

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 09 Jul 2020 English Publisher:MDPI AGJournal:Membranes, volume 10, page 147 (eissn: 2077-0375,

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Authors: Alba Gutierrez-Docio; Paula Almodóvar; Silvia Moreno-Fernandez; Jose Manuel Silvan; Adolfo J. Martinez-Rodriguez; Gonzalo Luis Alonso; Marin Prodanov;

doi: 10.3390/membranes10070147

pmid: 32660066

pmc: PMC7407673

handle: 10261/238297

Evaluation of an Integrated Ultrafiltration/Solid Phase Extraction Process for Purification of Oligomeric Grape Seed Procyanidins

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Abstract

The effectiveness of a preparative integrated ultrafiltration/solid-phase extraction (UF/SPE) process for purification of oligomeric procyanidins (OPCs) from a crude grape seed extract (GSE) was studied for the first time. The separation of OPCs from polymeric procyanidins (PPCs) by UF was very efficient. The membrane showed an acceptable filtration flux of 6 to 3.5 L/h·m2 at 0.5 bar of transmembrane pressure and 95% recovery of its water flux after chemical cleaning. The process was scalable to a pilot scale. The separation of very polar and ionic species from OPCs by SPE (XAD7HP and XAD16 resins) was also very good, but both adsorbents lost their retention capacities quickly, due probably to irreversible retention of OPCs/PPCs. Even though the global purification of OPCs by the integrated UF/SPE process allowed the recovery of 24.2 g of highly purified OPCs (83% purity) from 14.4 L of crude grape seed extract, the use of these adsorbents for further purification of the OPCs was very limited.

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Keywords

Solid-phase extraction, purification, tangential-flow pressure-driven membrane ultrafiltration, Chemical technology, oligomeric procyanidins, TP1-1185, Tangential-flow pressure-driven membrane ultrafiltration, Article, Chemical engineering, Oligomeric procyanidins, solid-phase extraction, TP155-156, grape seed extract, Purification, Grape seed extract

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