Downloads provided by UsageCountsMBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Copyright policy )NHMRC| How does dietary cholesterol induce non-alcoholic steatohepatitis? ,
NHMRC| MERTK receptor tyrosine kinase: A novel therapeutic target for liver fibrosis ,
NHMRC| Practitioner Fellowship ,
NHMRC| Hepatitis C infection: epidemiology, pathogenesis, and treatment
Thabet, K; Asimakopoulos, A; Shojaei, M; Romero-Gomez, M; Mangia, A; Irving, WL; Berg, T; +34 Authors
Thabet, K; Asimakopoulos, A; Shojaei, M; Romero-Gomez, M; Mangia, A; Irving, WL; Berg, T; Dore, GJ; Grønbæk, H; Sheridan, D; Abate, ML; Bugianesi, E; Weltman, M; Mollison, L; Cheng, W; Riordan, S; Fischer, J; Spengler, U; Nattermann, J; Wahid, A; Rojas, A; White, R; Douglas, MW; McLeod, D; Powell, E; Liddle, C; Van Der Poorten, D; George, J; Eslam, M; Gallego-Duran, R; Applegate, T; Bassendine, M; Rosso, C; Mezzabotta, L; Leung, R; Malik, B; Matthews, G; Grebely, J; Fragomeli, V; Jonsson, JR; Santaro, R;
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
AbstractCirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in theMBOAT7locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that theMBOAT7rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis.
Australia, United Kingdom, United Kingdom, China (People's Republic of), Italy
- University of Turin Italy
- University of Nottingham United Kingdom
- Westmead Hospital Australia
- Princess Alexandra Hospital Australia
- Hospital Universitario de Valme Spain
Liver Cirrhosis, Male, 32 Biomedical and Clinical Sciences, Chronic hepatitis C, Oral and gastrointestinal, Hepatitis, Hepatitis B Crónica, Cohort Studies, Genetics research, 2.1 Biological and endogenous factors, 3100 Physics and Astronomy, Chronic, 3202 Clinical Sciences, Hígado, Liver Disease, Q, Liver Neoplasms, 3 Good Health and Well Being, Single Nucleotide, Middle Aged, 1600 Chemistry, Hepatitis C, Infectious Diseases, International Liver Disease Genetics Consortium, Disease Progression, anzsrc-for: 3202 Clinical Sciences, Female, MBOAT7 rs641738 polymorphism, Carcinoma, Hepatocellular, 1300 Biochemistry, Science, Chronic Liver Disease and Cirrhosis, Liver fibrosis, 610, Genetics and Molecular Biology, Cirrosis Hepática, Polymorphism, Single Nucleotide, Liver fibrosis progression, Article, anzsrc-for: 32 Biomedical and Clinical Sciences, Clinical Research, Hepatitis C Crónica, Genetics, Journal Article, Hepatic inflammation, Humans, Polymorphism, Inflamación, Inflammatory and immune system, Carcinoma, Membrane Proteins, Hepatocellular, Hepatitis C, Chronic, Macrophage Activation, Fibrosis, Cirrosis Hepática Alcohólica, 620, Fatty Liver, Oxidative Stress, Case-Control Studies, Immune System, Liver cirrhosis, Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all), Digestive Diseases, Acyltransferases, Estrés Oxidativo
Liver Cirrhosis, Male, 32 Biomedical and Clinical Sciences, Chronic hepatitis C, Oral and gastrointestinal, Hepatitis, Hepatitis B Crónica, Cohort Studies, Genetics research, 2.1 Biological and endogenous factors, 3100 Physics and Astronomy, Chronic, 3202 Clinical Sciences, Hígado, Liver Disease, Q, Liver Neoplasms, 3 Good Health and Well Being, Single Nucleotide, Middle Aged, 1600 Chemistry, Hepatitis C, Infectious Diseases, International Liver Disease Genetics Consortium, Disease Progression, anzsrc-for: 3202 Clinical Sciences, Female, MBOAT7 rs641738 polymorphism, Carcinoma, Hepatocellular, 1300 Biochemistry, Science, Chronic Liver Disease and Cirrhosis, Liver fibrosis, 610, Genetics and Molecular Biology, Cirrosis Hepática, Polymorphism, Single Nucleotide, Liver fibrosis progression, Article, anzsrc-for: 32 Biomedical and Clinical Sciences, Clinical Research, Hepatitis C Crónica, Genetics, Journal Article, Hepatic inflammation, Humans, Polymorphism, Inflamación, Inflammatory and immune system, Carcinoma, Membrane Proteins, Hepatocellular, Hepatitis C, Chronic, Macrophage Activation, Fibrosis, Cirrosis Hepática Alcohólica, 620, Fatty Liver, Oxidative Stress, Case-Control Studies, Immune System, Liver cirrhosis, Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all), Digestive Diseases, Acyltransferases, Estrés Oxidativo
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).114 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1% views 51 downloads 77 - 51views77downloads
selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
Views provided by UsageCountsdownloadsDownloads provided by UsageCounts
Downloads provided by UsageCounts 114
Top 1%
Top 10%
Top 1%
51
77
Green
gold
