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University of Nottingham

Country: United Kingdom
501 Projects, page 1 of 101
  • Open Access mandate for Publications
    Funder: EC Project Code: 747208
    Overall Budget: 183,455 EURFunder Contribution: 183,455 EUR
    Partners: University of Nottingham

    Recent innovations in dynamic nuclear polarization (DNP) have transformed the sensitivity of solid-state nuclear magnetic resonance (NMR), resulting in a reduction in experiment time of up to 100,000-fold. This means that previously unobtainable structural details can be quickly obtained by NMR, even for dilute species, such as binding sites in catalysts or functionalizing molecules at surfaces. The objectives of the action are the improved sample preparation protocols, new experimental approaches and proof of principle studies necessary to make DNP-enhanced solid-state NMR the method of choice for the molecular-level characterization of the surfaces of materials. These objectives will be achieved by knowledge exchange between Dr S. Chaudhari, an experienced researcher with a background in developing DNP, and researchers at the University of Nottingham involved in solid-state NMR studies of materials and catalysts. The action is designed to train Dr Chaudhari though high-quality research into applications of DNP-enhanced solid-state NMR to four technologically useful materials: mesocellular silica foams, alumina catalyst supports, surface-coated hydroxyapatite nanoparticles and model catalytic converters. The training will take place at the state-of-the-art UK Facility for DNP-enhanced solid-state NMR operational at the University of Nottingham since November 2015. The Facility’s instrumentation is unique in the UK and is available to external users from both industry and academia, resulting in a vibrant research environment and a ready-made network of collaborators for Dr Chaudhari. In addition, a secondment at a leading sustainable technology company (Johnson Matthey) will ensure that industrial and commercial aspects are fully integrated into the action. The training will transform Dr Chaudhari into a creative and independent scientist working at the frontiers of DNP-enhanced NMR by providing him with the necessary research knowledge and transferable skills.

  • Funder: EC Project Code: 299084
    Partners: University of Nottingham
  • Funder: EC Project Code: 274326
    Partners: University of Nottingham
  • Funder: EC Project Code: 326581
    Partners: University of Nottingham
  • Open Access mandate for Publications
    Funder: EC Project Code: 840626
    Overall Budget: 149,951 EURFunder Contribution: 149,951 EUR
    Partners: University of Nottingham

    There is great need to develop safer and more biologically relevant models for drug screening. Recent reports indicate that up to 20% of acute kidney complications can be linked to drug-induced nephrotoxicity and more than 40 molecules found to reduce Alzheimer’s Disease (AD)-related plaques in animal models were shown to be ineffective in AD patients. It is increasingly evident that both in vitro and in vivo models being used to develop drugs have a limited capacity to predict the pathophysiology of human disease, personalized response, and off-target drug toxicity. The inability to properly test drugs and treatments to diseases such as AD constitutes a risk for pharmaceutical companies and a major obstacle to overcome. This ERC PoC proposal aims to establish a practical microfluidic fabrication process capable of recreating structural and biomechanical features of native blood vessels. Specifically, we aim to develop a scalable 3D Blood-Brain-Barrier in vitro model (BBB-on-a-chip) able to provide a higher level of biological relevance than current in vitro models. The development of such a system would represent a major break-through for the pharmaceutical industry generating therapies for a variety of neurological disorders. Thanks to the ERC Starting Grant STROFUNSCAFF, we have developed a simple fabrication process that combines bioprinting and self-assembly to grow functional fluidic devices with endothelialized vessel-like capillaries (patent application in preparation). NOVACHIP proposes to a) build scalable microfluidic devices made from capillaries that incorporate relevant cells and extracellular matrix (ECM) components, exhibit tissue-like stiffness, and can be designed with specific sizes and geometries to better resemble the native BBB and b) compare it to a commercially available in vitro model as well as c) an established rat model by quantifying permeability of specific imaging biomarkers for Magnetic Resonance Imaging (MRI) technique.