The industrial district of Castellon is characterized by a great dynamism based on technological innovation, both product and process, the origins of which are to be found on its providers (1), the machinery industry and the frit, glaze and colours industry. In this paper the current situation of the frit, glaze and colour industry is analyzed, accounting also for the situation of its main European competitor in Italy. The formation and development of the industry is also described in relation to the industrial district and the innovation system where it belongs, together with the R&D activity, the innovation activity, and the main technological milestones that have made it become the world leader. The analysis shows the challenges to which this subsector, and more generally, the tile innovation system need to react to, by means of cooperation, in order to maintain the tile district leadership. Globalization implies new behaviours and one of the most relevant is the increase of cooperation among the different actors in the innovation system.