Biological control of plant diseases is an important component of disease management, particularly in the today’s’ world of environmental consciousness and awareness. It is particularly preferred method of disease management under organic production system. Biological control is successful in almost all the crops against a number of diseases but soil borne diseases are most responsive to bio-control methods. The agents of biological control, known as bio-control agents (BCAs) belong to a vast group of micro-organisms, particularly fungi (Trichoderma, Ampelomyces, etc), bacteria (Pseudomonas, Bacillus, etc) and actinomycetes. Bottle gourd is an important vegetable crop belonging to the family Cucurbitaceae. It suffers from a number of diseases like anthracnose, powdery mildew, downy mildew, wilt, etc. The present review shall be an attempt to review the biological control of the major diseases of bottle gourd.