Jellyfish stings are common in Thailand. Stings can range from mild skin irritation to severe systemic symptoms resulting in death. Jellyfish envenomation is becoming an important public health concern. The lethal box jellyfish and bluebottle jellyfish are found on the Gulf of Thailand and Andaman coasts, but there are still misconception and mismanagement of these types of severe stings. Prevention and awareness of jellyfish stings are important, as well as knowledge and first aid management of severe envenomation. Educational programmes should be provided to locals including school children, teachers, hotel and tour operators, and medical staff. This will greatly reduce the morbidity and mortality associated with fatal stings.