Agriculture plays a most important role in our Indian economy and therefore lowering the cost of production and improving the quality of agricultural products is highly demanded. A weed is a plant which grows in wrong place at the wrong time and doing mostly harm than crops. Weed competes with the crops for water, light, nutrients and space, and therefore it prevents crop yields. This paper proposes a new method in a contrary way, which combines deep learning and image processing technology to prevent these weeds. Machine learning technologies, are becoming crucial in agriculture to increase productivity, where advanced automation and control have been required. Based on large training datasets and pre-trained models, (Deep Learning) DL-based Convolutional Neural Networks (CNN) methods have proven to be more accurate than previous traditional techniques. Recently, Deep Learning (DL) has gained much attention due to its advantages in object detection, classification, and feature extraction. The system implementation of image processing technique for weed detection, a trained image is taken as a sample in order to demonstrate the difference between weed and the crop. Yolo frame work is used for annotate boundary boxes to the image with datasets. The effectiveness of the (You Only Live Once) YOLO-WEED system for real-time Unmanned Aerial Vehicle (UAV) weed detection, given its high speed and high accuracy in detection. After certain steps, we get desired output, where the weeds are separated from the crop that has been taken in the sample image. Key Words: DeepLearning,CNN, Unmanned Aerial Vehicle (UAV), Precision Weed Detection.