In dentistry, cavities prepared with Erbium lasers present more advantages, compared to traditional methods, but there is still a lack of investigation about the adhesion in dentin surfaces prepared with Erbium lasers, especially with Erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser.The purpose of this systematic review was to find out which might be "The most adequate adhesive and laser parameters for adhesion in dentin prepared with Er,Cr:YSGG laser."An electronic search was performed in the PubMed database. The search was limited to studies between 2009 and 2016.Ten articles were selected to the systematic review according to TRANSPARENT REPORTING of Systematic Reviews and Meta-ANALYSES checklist.The adhesive that showed the best bond strength results in dentin prepared with Er,Cr:YSGG laser was the self-adhesive Clearfil™ SE (Kuraray), with preconditioning with 40% phosphoric acid. The settings 2 W, 75% water, 60% air, 140 μs pulse duration, and 20 Hz showed the best adhesion outcome.