Dissochaeta is a plant genus of woody climbers, classified in the tribe Dissochaeteae (Melastomataceae). The taxonomic history of the genus is complicated and includes some allied genera like Dalenia, Diplectria, Macrolenes and Omphalopus. Most of them are already regarded as synonyms of Dissochaeta except for Macrolenes which is considered a separate genus here as well. Dissochaeta is characterised by its scrambling habit, interpetiolar outgrowths, 4-merous flowers, dimorphic stamens and berry-like fruits. A taxonomic revision of Dissochaeta is presented, which includes references, a complete list of synonyms, detailed morphological descriptions of the species and an identification key, as well as information on the distribution, habitat and ecology, vernacular names, notes and lists of examined specimens. Fifty four species and two varieties of Dissochaeta are recognised. We designate several lectotypes, propose eleven new combinations and we describe one new species and one new variety.