The bacterium that causes Pierce's disease (Xylella fastidiosa) is transmitted to grapevines by the glassy-winged sharpshooter (GWSS). Insecticides were evaluated for efficacy and residual activity against adult GWSS on grapevines. Ten insecticides were tested in the cyclo-chlorinated, carbamate, organic phosphate, pyrethroid and neonicotinoid chemical classes. Results from field trials indicate that the pyrethroids and neonicotinoids are promising control agents. Information on efficacious and environmentally compatible chemical control will be helpful in developing integrated pest management to protect California vineyards from Pierce's disease, as well as insecticide resistance management within crop-management production systems.