A set $S\subseteq\{0,1\}^E$ of binary vectors, with positions indexed by $E$, is said to be a powerful code if, for all $X\subseteq E$, the number of vectors in $S$ that are zero in the positions indexed by $X$ is a power of 2. By treating binary vectors as characteristic vectors of subsets of $E$, we say that a set $S\subseteq2^E$ of subsets of $E$ is a powerful set if the set of characteristic vectors of sets in $S$ is a powerful code. Powerful sets (codes) include cocircuit spaces of binary matroids (equivalently, linear codes over $\mathbb{F}_2$), but much more besides. Our motivation is that, to each powerful set, there is an associated nonnegative-integer-valued rank function (by a construction of Farr), although it does not in general satisfy all the matroid rank axioms.In this paper we investigate the combinatorial properties of powerful sets. We prove fundamental results on special elements (loops, coloops, frames, near-frames, and stars), their associated types of single-element extensions, various ways of combining powerful sets to get new ones, and constructions of nonlinear powerful sets. We show that every powerful set is determined by its clutter of minimal nonzero members. Finally, we show that the number of powerful sets is doubly exponential, and hence that almost all powerful sets are nonlinear.