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Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
Copyright policy )MDPIBaseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to &ldquo
. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m2 vs. 36.8 kg/m2 and 36.1 kg/m2, 12 months: 27.0 kg/m2 vs. 34.4 and 32.8 kg/m2) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%
12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.
Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients&rsquo
No NAFLD&rdquo
NAFL&rdquo
NASH&rdquo
or &ldquo
, &ldquo
- University of Cologne Germany
- University of Freiburg Germany
- RWTH Aachen University Germany
- University Hospital Bonn Germany
- Johann Wolfgang Goethe-Universität am Main Germany
Medical Subject Headings: nutritional and metabolic diseases digestive system diseases
Microsoft Academic Graph classification: Gastric bypass surgery medicine.disease_cause medicine Gastric bypass business.industry business Fatty liver medicine.disease Total body Weight loss medicine.symptom Internal medicine medicine.medical_specialty Gastroenterology Cohort study Excessive weight loss Morbid obesity
Library of Congress Subject Headings: lcsh:Medicine lcsh:R
Dewey Decimal Classification: ddc:610
Article, Roux-en-Y gastric bypass, one anastomosis gastric bypass, mini gastric bypass, NAFLD, NASH, weight loss, General Medicine, SIMPLE NONINVASIVE INDEX, BARIATRIC SURGERY, SIGNIFICANT FIBROSIS, SLEEVE GASTRECTOMY, SCORING SYSTEM, VALIDATION
Article, Roux-en-Y gastric bypass, one anastomosis gastric bypass, mini gastric bypass, NAFLD, NASH, weight loss, General Medicine, SIMPLE NONINVASIVE INDEX, BARIATRIC SURGERY, SIGNIFICANT FIBROSIS, SLEEVE GASTRECTOMY, SCORING SYSTEM, VALIDATION
Medical Subject Headings: nutritional and metabolic diseases digestive system diseases
Microsoft Academic Graph classification: Gastric bypass surgery medicine.disease_cause medicine Gastric bypass business.industry business Fatty liver medicine.disease Total body Weight loss medicine.symptom Internal medicine medicine.medical_specialty Gastroenterology Cohort study Excessive weight loss Morbid obesity
Library of Congress Subject Headings: lcsh:Medicine lcsh:R
Dewey Decimal Classification: ddc:610
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
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- University of Cologne Germany
- University of Freiburg Germany
- RWTH Aachen University Germany
- University Hospital Bonn Germany
- Johann Wolfgang Goethe-Universität am Main Germany
weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to &ldquo
. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m2 vs. 36.8 kg/m2 and 36.1 kg/m2, 12 months: 27.0 kg/m2 vs. 34.4 and 32.8 kg/m2) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%
12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.
Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients&rsquo
No NAFLD&rdquo
NAFL&rdquo
NASH&rdquo
or &ldquo
, &ldquo