This article documents Open access article processing charges (OA APC) Main 2016. This dataset was developed as part of a longitudinal study of the minority (about a third) of the fully open access journals that use the APC business model. APC data for 2016, 2015, 2014, and 2013 are primarily obtained from publishers’ websites, a process that requires analytic skill as many publishers offer a diverse range of pricing options, including multiple currencies and/or differential pricing by article type, length or work involved and/or discounts for author contributions to editing or the society publisher or based on perceived ability to pay. This version of the dataset draws heavily from the work of Walt Crawford, and includes his entire 2011–2015 dataset; in particular Crawford’s work has made it possible to confirm “no publication fee” status for a large number of journals. DOAJ metadata for 2016 and 2014 and a 2010 APC sample provided by Solomon and Björk are part of the dataset. Inclusion of DOAJ metadata and article counts by Crawford and Solomon and Björk provide a basis for studies of factors such as journal size, subject, or country of publication that might be worth testing for correlation with business model and/or APC size.