Our study presents the computational implementation of an air lubrication system on a commercial ship with 154,800 m3 Liquified Natural Gas capacity. The air lubrication reduces the skin friction between the ship’s wetted area and sea water. We analyze the real operating conditions as well as the assumptions, that will approach the problem as accurately as possible. The computational analysis is performed with the ANSYS FLUENT software. Two separate geometries (two different models) are drawn for a ship’s hull: with and without an air lubrication system. Our aim is to extract two different skin friction coefficients, which affect the fuel consumption and the CO2 emissions of the ship. A ship’s hull has never been designed before in real scale with air lubrication injectors adjusted in a computational environment, in order to simulate the function of air lubrication system. The system’s impact on the minimization of LNG transfer cost and on the reduction in fuel consumption and CO2 emissions is also examined. The study demonstrates the way to install the entire system in a new building. Fuel consumption can be reduced by up to 8%, and daily savings could reach up to EUR 8000 per travelling day.