Hemp (Cannabis sativa L.) is an emerging high-value specialty crop that can be cultivated foreither fiber, seed, or cannabidiol (CBD). The demand for hemp and its products has been consistently onthe rise in the 21st century. The United States of America has reintroduced hemp and legalizedits production as an agricultural commodity through the 2018 Federal Farm Bill. Although thereis a renewed interest in the adoption of hemp due to the emerging market, its production in theUnited States remains limited partly because of unclear agronomic guidance and fertilizationrecommendations. This review article provides information on the current agronomic managementpractices that are available in the literature and identifies the future research needs for cultivating thismultipurpose crop to address the growing market demands. Hemp production could be beneficialif managed properly. Hemp fertilizer requirements vary in accordance with the type of hempgrown (seed, fiber, or CBD), soil, environmental conditions and requires a wide range of macro- andmicronutrients. Integrating management practices in hemp cultivation intended to build soil health ispromising since the hemp cropping system is suitable for crop rotation, cover cropping, and livestockintegration through animal waste applications. Hemp also has significant environmental benefitssince it has the potential to remediate contaminated soils through phytoremediation, convert highamounts of atmospheric CO2 to biomass through bio-sequestration, and hemp biomass for bioenergyproduction. This review identifies that most of the agronomic research in the past has been limitedto hemp fiber and, to some extent, hemp seed but not CBD hemp. With the increase in the globalmarkets for hemp products, more research needs to be conducted to provide agronomic guidelinesfor sustainable hemp production.