‘The Anthropocene’ is a term that is increasingly used to define a new planetary epoch: one in which humans have become the dominant force shaping Earth’s bio-geophysical composition and processes. Although it originated in the Earth Sciences, it has since been widely adopted across academia and the public sphere as a catch-all description for the overwhelming impact of human activity on the planet. This entry examines how anthropologists have engaged with the Anthropocene, both as a set of phenomena (e.g. climate change, mass extinction) and as a politically and morally loaded concept. It identifies four main anthropological approaches to the Anthropocene, those that: 1) take the Anthropocene as a context for or backdrop to ethnographic inquiry; 2) interrogate ‘the Anthropocene’ as a socially and politically constructed idea; 3) treat the Anthropocene as an opportunity for creativity and hopeful speculation; and 4) view the Anthropocene as the outcome of long-standing global political and socio-economic inequalities. Such approaches entail distinct methods, analytical frameworks, concepts, and ethico-political programmes. Collectively, they form a large and still-evolving body of work that destabilizes divisions between ‘nature’ and ‘culture’ and ‘humans’ and ‘non-humans’, as well as the scholarly disciplines traditionally built around them. In this capacity, they are also pushing anthropologists to ask what distinctive methodological, analytical, and ethico-political contributions their discipline can make to the burgeoning interdisciplinary field of Anthropocene studies.