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EFSA Journal
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EFSA Journal
Article . 2012
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Scientific opinion on the safety of smoke flavouring Primary Product SmokEz Enviro 23 ‐ 2012 Update

Authors: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF);

Scientific opinion on the safety of smoke flavouring Primary Product SmokEz Enviro 23 ‐ 2012 Update

Abstract

Abstract The EFSA CEF Panel updated the safety assessment of the smoke flavouring Primary Product SmokEz Enviro 23. In 2009, the Panel concluded that the margins of safety for this Primary Product were insufficient and the proposed use levels were considered of safety concern. After the opinion of 2009 the Panel received new data i.e. new use levels, chemical data and a new 90‐day toxicity study, which resulted in this update of the previous opinion. The new chemical data provided demonstrate that the test material used in the new 90‐day toxicity study is representative of the Primary Product evaluated by EFSA. Based on the findings from the 90‐day study submitted in 2009 and from the newly submitted one, the Panel derived a NOAEL for Primary Product SmokEz Enviro 23 of 598 mg/kg bw/day based on absolute and relative kidney weight changes in female rats. Based on newly submitted normal use levels, the margins of safety are 62 and 77 (total dietary exposure) and 65 and 89 (use in traditionally smoked foods only) depending on the exposure scenario used. Given that these margins of safety are based on 90‐day toxicity studies, and given the absence of data on reproduction, developmental toxicity and of long term studies, it is concluded that the uses and use levels of Primary Product would require a larger margin of safety. The Panel concluded that the proposed use of the Primary Product at the uses and use levels specified is of safety concern.

Keywords

Smoke flavouring, Nutrition. Foods and food supply, Chemical technology, TX341-641, TP1-1185, SmokEz Enviro 23, Primary Product

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold